Manuka Honey and Zein Coatings Impart Bioactive Glass Bone Tissue Scaffolds Antibacterial Properties and Superior Mechanical Properties

The combination of traditional herbal medicine (phytotherapeutic agents) with bioactive glasses is a promising strategy to generate advanced scaffolds for bone tissue engineering (BTE). An old remedy used wound care since ancient times honey. antioxidant, antimicrobial and antibacterial properties Manuka honey, in particular, make it an attractive substance application BTE prevent infections biofilm formation. In this study 45S5 glass-based produced via the foam replica technique were coated corn protein zein honey two purposes: improve mechanical brittle impart properties. morphology chemical composition characterized scanning electron microscopy Fourier transform infrared spectroscopy, respectively, demonstrating presence coating. release was quantified ultraviolet-visible spectrophotometry; moreover, activity against Staphylococcus aureus evaluated colony-forming units counting, reduction Alamar blue turbidity measurements. Our findings suggest effective glass, adding one more system novel family glass functionalized phytotherapeutic agents.